• Stuart as Ed
  • Gru as Edd
  • Kevin as Eddy
  • Young Once-ler (from Dr. Seuss' The Lorax) as Rolf
  • Jorge as Nazz
  • Tim as Kevin
  • Jerry as Jimmy
  • Scarlett as Sarah
  • Silas Ramsbottom (from Despicable Me 2) as Johnny
  • Mark as Lee Kanker
  • Ted's Mom (from Dr. Seuss' The Lorax) as Marie Kanker
  • Lucy Wilde (from Despicable Me 2) as May Kanker
  • Herb as Eddy's Brother